After returning the body of Gus McCrae to Lonesome Dove, Woodrow Call takes on the challenge of driving a herd of wild mustangs 2500 miles north to the Hat Creek Ranch in Montana. But tragedy, triumph, despair and deceit will greet him before he ever gets there.

Jon Voight, Barbara Hershey, Ricky Schroder, William Petersen, Oliver Reed, Dennis Haysbert, Reese Witherspoon, Timothy Scott, Chris Cooper, CCH Pounder, Nia Peeples, Barry Tubb, William Sanderson, Veronica Lauren, Molly Orr, Louis Gossett Jr., David Carpenter, León Singer, Jack Caffrey, Reginald T. Dorsey, Dylan Baker, Colin Fox, John Quade, Nick Searcy, Peter Gerety, Scott Burkholder, John Speredakos