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The guys see an attractive woman in Sheldon's office, and they become even more surprised when Sheldon introduces her as his fraternal twin sister, Missy (Courtney Henggeler). After meeting her, Raj decides to take part in a drug trial to cure his inability to talk to women, and Leonard insists she stay with them at the apartment. Of course, the men begin awkwardly flirting with her, causing Penny to come to her rescue.

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